Description

Overview
Tesamorelin (TH9507) is a synthetic analogue of endogenous Growth Hormone Releasing Hormone (GHRH), consisting of the full 44 amino acid sequence of human GHRH with the addition of a trans-3-hexenoic acid group at the N-terminus. This strategic molecular modification significantly enhances the peptide’s stability against plasma dipeptidyl peptidase IV (DPP-IV) degradation while preserving its full biological activity at the GHRH receptor. As a result, Tesamorelin exhibits a markedly extended half-life compared to native GHRH, making it an exceptionally valuable and well-characterised research tool for investigating the hypothalamic-pituitary-somatotropic (HPS) axis, growth hormone secretion dynamics, and the downstream metabolic effects of pulsatile GH stimulation. Apex Sequence Labs offers Tesamorelin at the highest purity standards, rigorously tested and manufactured under strict quality control protocols to ensure consistency and reliability for advanced scientific investigation.

Molecular Profile

Full Name: Tesamorelin (TH9507)
Type: Synthetic GHRH Analogue | Growth Hormone Secretagogue
Sequence: Trans-3-hexenoic acid-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH?
Molecular Formula: C???H???N??O??S
Molecular Weight: ~5135.8 g/mol
CAS Number: 218949-48-5
Purity: 99% (HPLC verified)
Form: Lyophilized powder
Modification: Trans-3-hexenoic acid at N-terminus
Half-Life: Approximately 26–38 minutes (significantly extended vs native GHRH)

Research Areas of Interest
Tesamorelin has established itself as one of the most rigorously studied GHRH analogues in biomedical research, with a scientific profile that spans endocrinology, metabolic science, neuroscience, and body composition research:

Hypothalamic-Pituitary-Somatotropic (HPS) Axis Research – As a full-length GHRH analogue with preserved receptor binding fidelity, Tesamorelin serves as an exceptionally well-characterised research tool for studying the dynamics of the HPS axis. Research has extensively utilised Tesamorelin to investigate pulsatile growth hormone secretion patterns, somatotroph responsiveness, somatostatin interplay, and the regulatory feedback mechanisms governing GH release, providing researchers with a highly reliable and reproducible model of physiological GHRH activity.
Growth Hormone Secretion & IGF-1 Research – The most directly studied effect of Tesamorelin is its capacity to stimulate endogenous growth hormone secretion from anterior pituitary somatotrophs through GHRH receptor activation. Research has explored how Tesamorelin-stimulated GH pulses influence downstream IGF-1 production, IGF binding protein profiles, and the systemic effects of restored physiological GH secretion patterns across multiple tissue types, making it a uniquely valuable tool for studying the GH/IGF-1 axis in controlled experimental settings.
Visceral Adipose Tissue & Body Composition Research – Among the most extensively studied applications of Tesamorelin, research has documented its significant effects on visceral adipose tissue (VAT) reduction and body composition remodelling. Studies have explored the mechanisms by which GH-mediated lipolysis, enhanced fatty acid oxidation, and altered adipokine profiles contribute to selective visceral fat reduction, with particular research interest in the differential effects on visceral versus subcutaneous adipose compartments.
Metabolic & Lipid Research – Investigated for its effects on lipid metabolism, including reductions in triglycerides, improvements in lipoprotein profiles, and enhancement of fatty acid oxidation pathways. Research has explored how Tesamorelin-stimulated GH secretion influences hepatic lipid metabolism, peripheral lipolysis, and overall metabolic flexibility across different physiological and pathological states.
Cognitive & Neurological Research – An increasingly prominent area of Tesamorelin research, studies have explored its potential effects on cognitive function, brain structure, and neurological health. Research has investigated its influence on hippocampal volume, white matter integrity, executive function, and memory performance in various study populations, with growing scientific interest in the potential relationship between GH/IGF-1 axis activity and cognitive ageing.
Cardiovascular Research – Studied for its potential cardioprotective and cardiometabolic effects, including improvements in endothelial function, reductions in carotid intima-media thickness (CIMT), modulation of inflammatory cardiovascular risk markers, and effects on cardiac structure and function in models of GH deficiency and metabolic disease.
HIV-Associated Lipodystrophy Research – Tesamorelin has been extensively studied in the context of HIV-associated lipodystrophy syndrome (HALS), a metabolic complication characterised by abnormal fat redistribution associated with antiretroviral therapy. Research has documented its significant effects on visceral fat reduction and metabolic marker improvement in this specific research population, providing a well-characterised clinical research model for studying lipodystrophic metabolic dysfunction.
Bone Metabolism & Musculoskeletal Research – Investigated for its effects on bone mineral density, bone turnover markers, and skeletal integrity through GH/IGF-1 axis stimulation. Research has also explored Tesamorelin’s potential effects on lean muscle mass preservation, muscle strength, and functional capacity in models of GH insufficiency and age-related somatopause.
Ageing & Somatopause Research – A significant area of scientific interest, research has explored Tesamorelin as a tool for studying the phenomenon of somatopause — the age-related decline in GH secretory amplitude and IGF-1 levels — and its contribution to the metabolic, body composition, cognitive, and musculoskeletal changes associated with normal ageing. Studies have investigated Tesamorelin-mediated GH restoration as a model for understanding the biological consequences of somatopause and GH insufficiency in aged subjects.
Quality of Life & Functional Research – Studied in models of GH insufficiency for its effects on energy levels, physical performance, sleep quality, and overall functional capacity, contributing to a broader understanding of the physiological role of the GH/IGF-1 axis in maintaining vitality and functional health across the lifespan.

What Sets Tesamorelin Apart?
Tesamorelin’s unique scientific profile stems from its combination of structural precision and physiological fidelity:

Full-Length GHRH Sequence – Unlike truncated GHRH fragments, Tesamorelin retains the complete 44 amino acid GHRH sequence, ensuring full receptor binding affinity and preserved biological activity across all GHRH receptor-mediated research applications
N-Terminal Trans-3-Hexenoic Acid Modification – This strategic structural addition confers significantly enhanced resistance to DPP-IV degradation compared to native GHRH, dramatically extending research utility while maintaining complete receptor specificity
Physiological GH Secretion Pattern – Unlike direct GH administration, Tesamorelin stimulates endogenous pulsatile GH release through the natural pituitary axis, preserving the physiological feedback mechanisms and pulsatile secretion dynamics that are critical to authentic GH biology research
Preserved Hypothalamic Feedback Sensitivity – Because Tesamorelin acts through the GHRH receptor rather than bypassing the pituitary axis, it maintains the natural somatostatin-mediated feedback loop, providing researchers with a more physiologically representative model of GH secretion than exogenous GH administration
Extensive Clinical Research Base – With a substantial body of peer-reviewed clinical research and regulatory evaluation, Tesamorelin is one of the most comprehensively characterised GHRH analogues available, providing researchers with an exceptionally well-validated reference compound

Quality Assurance
All Apex Sequence Labs peptides are:

Synthesized using advanced solid-phase peptide synthesis (SPPS)
N-terminal modification verified through analytical testing
Third-party tested via HPLC and Mass Spectrometry
Produced in a controlled, sterile, ISO-compliant laboratory environment
Supplied with a Certificate of Analysis (CoA) available upon request

Packaging & Storage

Available in: 2mg | 5mg | 10mg vials
Storage: Store lyophilized peptide at 20°C away from light and moisture
Once reconstituted: Store at 4°C and use within 28 days
Recommended diluent: Bacteriostatic water or sterile water for injection
Shelf life: 24 months when stored correctly in lyophilized form

Why Choose Apex Sequence Labs?

– 99% purity guaranteed
– Independent third-party testing on every batch
– Certificate of Analysis provided
– N-terminal modification analytically verified
– Produced in ISO-compliant cleanroom facilities
– Fast, discreet shipping
– Dedicated researcher support team

– Research Use Only Disclaimer
Tesamorelin supplied by Apex Sequence Labs is intended strictly for in vitro and in vivo laboratory research purposes only. This product is NOT intended for human or veterinary use, is NOT a drug or dietary supplement. While Tesamorelin (brand name Egrifta®) is an FDA-approved pharmaceutical product indicated for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy, the research-grade Tesamorelin supplied by Apex Sequence Labs is an independently synthesised research compound and is not affiliated with, endorsed by, or equivalent to any approved pharmaceutical product. By purchasing this product, the buyer confirms they are a qualified researcher and accepts full responsibility for its lawful and ethical use in accordance with all applicable local, state, and federal regulations.